Dr Basile Chrétien

Senior Pharmacologist
ORCID: 0000-0002-7483-2489
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Basile Chrétien

As a passionate Senior Pharmacologist and Hospital Practitioner with over 10 years of experience in drug safety, pharmacoepidemiology, and toxicology, I specialize in leveraging biostatistics, database management, and machine learning to drive innovative, data-driven research in medicine. I also serve as a pharmacovigilance expert for France's medicines safety agency (ANSM) and develop open, reproducible research tools, including the vigicaen R package on CRAN, Open Editors Plus, and SigmaCV. In 2024, I completed a Master's in Biostatistics at Paris-Saclay University to strengthen my analytical skills and expand my use of machine learning, which I now apply daily in my research. I am currently in the second year of my PhD in International Medical Education at Nagoya University's Graduate School of Medicine, where I am developing an active-learning web platform in medicine for integration into the curricula of Nagoya and Caen universities. This project aims to improve medical education through culturally inclusive, adaptive learning environments supported by machine-learning-based outcome analysis. I also co-lead CANAL-AI, a Caen–Nagoya federated-learning collaboration applying privacy-preserving machine learning to cardiovascular outcomes in cancer patients across French and Japanese health data. Beyond this, I contribute as a biostatistician and author across numerous research projects, with more than 100 peer-reviewed publications. I thrive in international environments and am dedicated to building bridges across cultures. My interest in Japan is both professional and personal, and I passed the JLPT N1 in December 2023. よろしくお願いいたします。

Research summary

  • Mean work FWCI 1.3 — 1.0 = world average for field & year · mean over 109 works with FWCI
  • 3 Datasets & Software
  • 1 Patents

PositionsPositions

  1. PhD Candidate2024–present
    Graduate School of Medicine · Nagoya University
  2. Senior Pharmacologist2016–2024
    Department of Pharmacology · Centre Hospitalier Universitaire de Caen Normandie

EducationEducation

  1. Master of Public health in Biostatistics2023–2024
    Medicine · University of Paris-Saclay
  2. Postgraduate Diploma in Pharmacology (equivalent to Board certification)2016–2018
    Medicine · University of Caen Normandy
  3. Master of Toxicology2017–2018
    Pharmacy · Université Paris Descartes
  4. PharmD (Hospital Pharmacy)2007–2016
    Pharmacy · University of Caen Normandy

Datasets & SoftwareDatasets & Software

  1. Chrétien, B. SigmaCV. Zenodo (2026) [Software]. https://doi.org/10.5281/zenodo.20594123
  2. Chretien, B. Open Editors Plus 2026: Editorial Board Composition of 15,000+ Academic Journals. Zenodo (2026) [Dataset]. https://doi.org/10.5281/zenodo.19468382
  3. Dolladille, C., & Chrétien, B. (2025). vigicaen: “VigiBase” Pharmacovigilance Database Toolbox [Dataset]. https://doi.org/10.32614/cran.package.vigicaen
    OAlast3 citations
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    Full text
    Abstract

    Perform the analysis of the World Health Organization (WHO) Pharmacovigilance database 'VigiBase' (Extract Case Level version), <https://who-umc.org/> e.g., load data, perform data management, disproportionality analysis, and descriptive statistics. Intended for pharmacovigilance routine use or studies. This package is NOT supported nor reflect the opinion of the WHO, or the Uppsala Monitoring Centre. Disproportionality methods are described by Norén et al (2013) <doi:10.1177/0962280211403604>.

Grants & FundingGrants & Funding

  1. Machine Learning-Driven Adaptive Problem Based Learning in Psychopharmacology: A Fra nco-Japanese Cross-Cultural Collaboration for Optimizing Medical Education, Nagoya Daigaku (2025–2029)
  2. PARANAC, University of Caen Normandy

PatentsPatents

  1. COMBINATIONS OF ACETAMINOPHEN AND N-ACETYL CYSTEINE FOR THE TREATMENT OF PAIN AND FEVER, CENTRE HOSPITALIER UNIV DE CAEN NORMANDIE [FR] (2023) [EP4238559]

Peer ReviewPeer Review

  1. Naunyn-Schmiedeberg s Archives of Pharmacology — 24 reviews
  2. Scientific Reports — 14 reviews
  3. BMC Pharmacology and Toxicology — 8 reviews
  4. European Journal of Clinical Pharmacology — 4 reviews
  5. DARU Journal of Pharmaceutical Sciences — 4 reviews
  6. Cardiovascular Toxicology — 2 reviews
  7. BMC Oral Health — 2 reviews
  8. BMC Endocrine Disorders — 2 reviews
  9. Clinical Nutrition ESPEN — 2 reviews
  10. Therapeutic Advances in Psychopharmacology — 2 reviews
  11. British Journal of Clinical Pharmacology — 2 reviews
  12. PLoS ONE — 2 reviews
  13. BMC Psychiatry — 3 reviews
  14. BMC Ophthalmology — 1 review
  15. BMC Gastroenterology — 1 review
  16. Lung — 1 review
  17. Archives of Dermatological Research — 1 review
  18. Cell Biology and Toxicology — 1 review
  19. Discover Medicine — 1 review
  20. Egyptian Pediatric Association Gazette — 1 review
  21. Clinical Therapeutics — 1 review
  22. Translational Psychiatry — 1 review
  23. Communications Medicine — 1 review
  24. World Journal of Surgical Oncology — 1 review
  25. BMC Neurology — 1 review
  26. BMC Cancer — 1 review
  27. BMC Pediatrics — 1 review
  28. American Journal of Clinical Dermatology — 1 review
  29. BMC Pregnancy and Childbirth — 1 review
  30. Clinical Drug Investigation — 1 review

Updated Jun 30, 2026 · living CV, updates automatically

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