Research summary
- Mean work FWCI 1.3 — 1.0 = world average for field & year · mean over 109 works with FWCI
- 2 Preprints
- 2 Datasets & Software
- 1 Patents
PositionsPositions
- PhD Candidate2024–presentGraduate School of Medicine · Nagoya University
- Senior Pharmacologist2016–2024Department of Pharmacology · Centre Hospitalier Universitaire de Caen Normandie
EducationEducation
- Master of Public health in Biostatistics2023–2024Medicine · University of Paris-Saclay
- Postgraduate Diploma in Pharmacology (equivalent to Board certification)2016–2018Medicine · University of Caen Normandy
- Master of Toxicology2017–2018Pharmacy · Université Paris Descartes
- PharmD (Hospital Pharmacy)2007–2016Pharmacy · University of Caen Normandy
PreprintsPreprints
- Boudzoumou, E., Croix, M., Hessou, J., Quéreux, G., Nishida, K., Takeichi, T., Ebata, A., Chrétien, B., & L’ORPHELIN, J. M. (2026). Severe Immune-Related Adverse Events Are Associated with Reduced Clinical Benefit in Advanced Melanoma: A Mechanistic National Multicentre Cohort Study. In SSRN Electronic Journal. https://doi.org/10.2139/ssrn.6261580OA0 citations
- Chrétien, B., Nishida, K., Kondo, T., Takahashi, N., Takami, H., Nishigori, H., Aleksić, B., Dolladille, C., Villalobos, I. B., Yagi, T., Skokauskas, N., & Kasuya, H. (2025). Comparing Traditional and Online Problem-Based Learning in Child and Adolescent Psychiatry in Nagoya: A Novel Statistical Approach in Japanese Educational Settings. In medRxiv. https://doi.org/10.1101/2025.05.08.25327243OAfirst0 citationsFull textPubMed
Abstract
BACKGROUND: Problem-Based Learning (PBL) requires active communication and learner autonomy, which can be challenging in cultural contexts that emphasize group harmony and indirect communication, such as Japan. This challenge is often amplified when PBL is conducted in a non-native language (English), potentially inducing "foreign language anxiety." While the COVID-19 pandemic necessitated a shift to online learning, the specific impact of this format on psychological barriers and student engagement in high-context cultures remains underexplored. We investigated whether the online format could reduce these transactional distances and enhance learning outcomes compared to traditional in-person PBL. METHODS: We conducted a naturalistic, historical control study comparing fourth-year medical students at Nagoya University during a Child and Adolescent Psychiatry curriculum. The 2019 cohort (n = 109) participated in-person, while the 2021 cohort (n = 100) participated online. We administered a 15-item questionnaire assessing satisfaction, engagement, and case suitability. Beyond standard descriptive comparisons, we applied a novel multidimensional statistical framework. This included Ordered Logistic Regression adjusted for age and sex to identify predictors of satisfaction, Exploratory Factor Analysis (EFA) to validate the instrument's latent structure, and K-means Clustering to identify distinct student "phenotypes" based on response patterns. RESULTS: The online cohort reported significantly higher satisfaction across most domains (Odds Ratios 0.36-0.51, p < 0.05). Factor analysis identified two primary dimensions-"Perceived Learning Efficacy" and "Engagement"-while "Communication Skills" (Question 4) emerged as an independent outlier, failing to load on either dimension. Cluster analysis identified two distinct student phenotypes: a "Traditional/Dissatisfied" profile (Cluster 1: n = 77, 69% from the in-person group, predominantly male and older) and a "Digital/Satisfied" profile (Cluster 2: n = 127, 57% from the online group, predominantly female and younger). CONCLUSIONS: Online delivery of PBL was associated with significantly higher student satisfaction and engagement scores in this Japanese context. Because the study is observational (historical-cohort comparison with no randomisation), this association cannot be attributed causally to the modality, and the role of reduced foreign-language anxiety is an interpretive hypothesis that the present design does not directly test. The identification of distinct student phenotypes suggests that demographic factors (gender, age) and delivery modality interact to shape the learning experience. These findings advocate for a tailored pedagogical approach, where digital formats serve as a "safe harbor" for students with high communication apprehension.
Datasets & SoftwareDatasets & Software
- Chrétien, B. SigmaCV. Zenodo (2026) [Software]. https://doi.org/10.5281/zenodo.20594123
- Chretien, B. Open Editors Plus 2026: Editorial Board Composition of 15,000+ Academic Journals. Zenodo (2026) [Dataset]. https://doi.org/10.5281/zenodo.19468382
Grants & FundingGrants & Funding
- Machine Learning-Driven Adaptive Problem Based Learning in Psychopharmacology: A Fra nco-Japanese Cross-Cultural Collaboration for Optimizing Medical Education, Nagoya Daigaku (2025–2029)
- PARANAC, University of Caen Normandy
PatentsPatents
- COMBINATIONS OF ACETAMINOPHEN AND N-ACETYL CYSTEINE FOR THE TREATMENT OF PAIN AND FEVER, CENTRE HOSPITALIER UNIV DE CAEN NORMANDIE [FR] (2023) [EP4238559]
Peer ReviewPeer Review
- Naunyn-Schmiedeberg s Archives of Pharmacology — 24 reviews
- Scientific Reports — 14 reviews
- BMC Pharmacology and Toxicology — 8 reviews
- European Journal of Clinical Pharmacology — 4 reviews
- DARU Journal of Pharmaceutical Sciences — 4 reviews
- Cardiovascular Toxicology — 2 reviews
- BMC Oral Health — 2 reviews
- BMC Endocrine Disorders — 2 reviews
- Clinical Nutrition ESPEN — 2 reviews
- Therapeutic Advances in Psychopharmacology — 2 reviews
- British Journal of Clinical Pharmacology — 2 reviews
- PLoS ONE — 2 reviews
- BMC Psychiatry — 3 reviews
- BMC Ophthalmology — 1 review
- BMC Gastroenterology — 1 review
- Lung — 1 review
- Archives of Dermatological Research — 1 review
- Cell Biology and Toxicology — 1 review
- Discover Medicine — 1 review
- Egyptian Pediatric Association Gazette — 1 review
- Clinical Therapeutics — 1 review
- Translational Psychiatry — 1 review
- Communications Medicine — 1 review
- World Journal of Surgical Oncology — 1 review
- BMC Neurology — 1 review
- BMC Cancer — 1 review
- BMC Pediatrics — 1 review
- American Journal of Clinical Dermatology — 1 review
- BMC Pregnancy and Childbirth — 1 review
- Clinical Drug Investigation — 1 review