Dr Basile Chrétien

Senior Pharmacologist
Basile Chrétien

As a passionate Senior Pharmacologist and Hospital Practitioner with over 10 years of experience in drug safety, pharmacoepidemiology, and toxicology, I specialize in leveraging biostatistics, database management, and machine learning to drive innovative, data-driven research in medicine. I also serve as a pharmacovigilance expert for France's medicines safety agency (ANSM) and develop open, reproducible research tools, including the vigicaen R package on CRAN, Open Editors Plus, and SigmaCV. In 2024, I completed a Master's in Biostatistics at Paris-Saclay University to strengthen my analytical skills and expand my use of machine learning, which I now apply daily in my research. I am currently in the second year of my PhD in International Medical Education at Nagoya University's Graduate School of Medicine, where I am developing an active-learning web platform in medicine for integration into the curricula of Nagoya and Caen universities. This project aims to improve medical education through culturally inclusive, adaptive learning environments supported by machine-learning-based outcome analysis. I also co-lead CANAL-AI, a Caen–Nagoya federated-learning collaboration applying privacy-preserving machine learning to cardiovascular outcomes in cancer patients across French and Japanese health data. Beyond this, I contribute as a biostatistician and author across numerous research projects, with more than 100 peer-reviewed publications. I thrive in international environments and am dedicated to building bridges across cultures. My interest in Japan is both professional and personal, and I passed the JLPT N1 in December 2023. よろしくお願いいたします。

Research summary

  • Mean work FWCI 1.3 — 1.0 = world average for field & year · mean over 109 works with FWCI
  • 2 Preprints
  • 2 Datasets & Software
  • 1 Patents

PositionsPositions

  1. PhD Candidate
    Graduate School of Medicine · Nagoya University
  2. Senior Pharmacologist
    Department of Pharmacology · Centre Hospitalier Universitaire de Caen Normandie

EducationEducation

  1. Master of Public health in Biostatistics
    Medicine · University of Paris-Saclay
  2. Postgraduate Diploma in Pharmacology (equivalent to Board certification)
    Medicine · University of Caen Normandy
  3. Master of Toxicology
    Pharmacy · Université Paris Descartes
  4. PharmD (Hospital Pharmacy)
    Pharmacy · University of Caen Normandy

PreprintsPreprints

  1. Boudzoumou, E., Croix, M., Hessou, J., Quéreux, G., Nishida, K., Takeichi, T., Ebata, A., Chrétien, B., & L’ORPHELIN, J. M. (2026). Severe Immune-Related Adverse Events Are Associated with Reduced Clinical Benefit in Advanced Melanoma: A Mechanistic National Multicentre Cohort Study. In SSRN Electronic Journal. https://doi.org/10.2139/ssrn.6261580
    OA0 citations
  2. Chrétien, B., Nishida, K., Kondo, T., Takahashi, N., Takami, H., Nishigori, H., Aleksić, B., Dolladille, C., Villalobos, I. B., Yagi, T., Skokauskas, N., & Kasuya, H. (2025). Comparing Traditional and Online Problem-Based Learning in Child and Adolescent Psychiatry in Nagoya: A Novel Statistical Approach in Japanese Educational Settings. In medRxiv. https://doi.org/10.1101/2025.05.08.25327243
    OAfirst0 citations
    CiteBibTeX RIS CSL-JSON
    Full textPubMed
    Abstract

    BACKGROUND: Problem-Based Learning (PBL) requires active communication and learner autonomy, which can be challenging in cultural contexts that emphasize group harmony and indirect communication, such as Japan. This challenge is often amplified when PBL is conducted in a non-native language (English), potentially inducing "foreign language anxiety." While the COVID-19 pandemic necessitated a shift to online learning, the specific impact of this format on psychological barriers and student engagement in high-context cultures remains underexplored. We investigated whether the online format could reduce these transactional distances and enhance learning outcomes compared to traditional in-person PBL. METHODS: We conducted a naturalistic, historical control study comparing fourth-year medical students at Nagoya University during a Child and Adolescent Psychiatry curriculum. The 2019 cohort (n = 109) participated in-person, while the 2021 cohort (n = 100) participated online. We administered a 15-item questionnaire assessing satisfaction, engagement, and case suitability. Beyond standard descriptive comparisons, we applied a novel multidimensional statistical framework. This included Ordered Logistic Regression adjusted for age and sex to identify predictors of satisfaction, Exploratory Factor Analysis (EFA) to validate the instrument's latent structure, and K-means Clustering to identify distinct student "phenotypes" based on response patterns. RESULTS: The online cohort reported significantly higher satisfaction across most domains (Odds Ratios 0.36-0.51, p < 0.05). Factor analysis identified two primary dimensions-"Perceived Learning Efficacy" and "Engagement"-while "Communication Skills" (Question 4) emerged as an independent outlier, failing to load on either dimension. Cluster analysis identified two distinct student phenotypes: a "Traditional/Dissatisfied" profile (Cluster 1: n = 77, 69% from the in-person group, predominantly male and older) and a "Digital/Satisfied" profile (Cluster 2: n = 127, 57% from the online group, predominantly female and younger). CONCLUSIONS: Online delivery of PBL was associated with significantly higher student satisfaction and engagement scores in this Japanese context. Because the study is observational (historical-cohort comparison with no randomisation), this association cannot be attributed causally to the modality, and the role of reduced foreign-language anxiety is an interpretive hypothesis that the present design does not directly test. The identification of distinct student phenotypes suggests that demographic factors (gender, age) and delivery modality interact to shape the learning experience. These findings advocate for a tailored pedagogical approach, where digital formats serve as a "safe harbor" for students with high communication apprehension.

Datasets & SoftwareDatasets & Software

  1. Chrétien, B. SigmaCV. Zenodo (2026) [Software]. https://doi.org/10.5281/zenodo.20594123
  2. Chretien, B. Open Editors Plus 2026: Editorial Board Composition of 15,000+ Academic Journals. Zenodo (2026) [Dataset]. https://doi.org/10.5281/zenodo.19468382

Grants & FundingGrants & Funding

  1. Machine Learning-Driven Adaptive Problem Based Learning in Psychopharmacology: A Fra nco-Japanese Cross-Cultural Collaboration for Optimizing Medical Education, Nagoya Daigaku (2025–2029)
  2. PARANAC, University of Caen Normandy

PatentsPatents

  1. COMBINATIONS OF ACETAMINOPHEN AND N-ACETYL CYSTEINE FOR THE TREATMENT OF PAIN AND FEVER, CENTRE HOSPITALIER UNIV DE CAEN NORMANDIE [FR] (2023) [EP4238559]

Peer ReviewPeer Review

  1. Naunyn-Schmiedeberg s Archives of Pharmacology — 24 reviews
  2. Scientific Reports — 14 reviews
  3. BMC Pharmacology and Toxicology — 8 reviews
  4. European Journal of Clinical Pharmacology — 4 reviews
  5. DARU Journal of Pharmaceutical Sciences — 4 reviews
  6. Cardiovascular Toxicology — 2 reviews
  7. BMC Oral Health — 2 reviews
  8. BMC Endocrine Disorders — 2 reviews
  9. Clinical Nutrition ESPEN — 2 reviews
  10. Therapeutic Advances in Psychopharmacology — 2 reviews
  11. British Journal of Clinical Pharmacology — 2 reviews
  12. PLoS ONE — 2 reviews
  13. BMC Psychiatry — 3 reviews
  14. BMC Ophthalmology — 1 review
  15. BMC Gastroenterology — 1 review
  16. Lung — 1 review
  17. Archives of Dermatological Research — 1 review
  18. Cell Biology and Toxicology — 1 review
  19. Discover Medicine — 1 review
  20. Egyptian Pediatric Association Gazette — 1 review
  21. Clinical Therapeutics — 1 review
  22. Translational Psychiatry — 1 review
  23. Communications Medicine — 1 review
  24. World Journal of Surgical Oncology — 1 review
  25. BMC Neurology — 1 review
  26. BMC Cancer — 1 review
  27. BMC Pediatrics — 1 review
  28. American Journal of Clinical Dermatology — 1 review
  29. BMC Pregnancy and Childbirth — 1 review
  30. Clinical Drug Investigation — 1 review

Updated Jun 30, 2026 · living CV, updates automatically

SubscribeAdd this feed URL to your RSS reader: https://sigmacv.org/p/basile-chretien-453f107e40a2add08892/feed.xml

Save these publications to a reference manager (Zotero, Mendeley…) — your browser connector will detect them.

Made with SigmaCV

Section names brushed stroke by stroke · stroke order KanjiVG (CC BY-SA 3.0) · brush face Yuji Boku (SIL OFL)